The Eighteen-time-major winner and fifth in the world rankings, says Roger Federer made the decision in an attempt to continue the playing on ATP Tour "for many years to come".
The 35-year-old Federer added that will prepare for the grass and hard-court seasons, which is going to begin in the month of June.
"I need to recognise that scheduling will be the key to my longevity," Roger Federer said.
"Thus, along with me and my team concluded that playing just one event on clay was not in the best interest of my tennis and physical preparation for the remainder of the season.
"I will miss the fans from French who have always been very supportive and I look forward to seeing them next year at Roland Garros."
Last year the Swiss International missed the French Open through injury, the very first time Roger Federer will not compete in Paris since 1999 his debut.
Roger Federer won the tournament for only time in 2009 and is a four-time runner-up.