Author Archives: Sumit Sharma

New York: In an important step forward for personalising care for women with breast cancer, researchers have found that a molecular test can pinpoint which patients will have a very low risk of death from breast cancer even 20 years after diagnosis and tumour removal.

As a result, 'ultralow' risk patients could be treated less aggressively and overtreatment avoided, leading to fewer toxic effects.

"We can now test small node-negative breast cancers, and if they are in the ultralow risk category, we can tell women that they are highly unlikely to die of their cancers and do not need aggressive treatment, including radiation after lumpectomy," said lead author Laura Esserman, breast cancer specialist and surgeon with University of California Health System, or UC Health.

Oncologists have discussed the existence of ultralow risk tumours and expressed concern that they might be exacerbated by screening. 

But this study, published in the journal JAMA Oncology, provides the first evidence that it is possible to run a test at the time of diagnosis and identify them, according to Esserman. 

"This is an exciting advance because approximately 20-25 per cent of tumours diagnosed today may be ultralow risk," said Esserman, who is also a professor at University of California, San Francisco (UCSF). 

The medical community for many years has focused on identifying cancer early so that it can be cured or more easily treated. 

While this can benefit some patients, screening also can detect cancers that are extremely low risk and not life-threatening, which could lead to patients being overtreated. 

The issue is compounded because breast cancer can recur many years after diagnosis -- for low-grade tumours, the majority of the risk occurs after five years. 

Until now, tools that could reliably identify ultralow risk tumours at the time of diagnosis have not been available because physicians lacked the assurance that late recurrence could truly be avoided.

In the new study, researchers sought to determine whether a 70-gene test could accurately and reliably identify tumours with indolent, or slow-growing, behaviour to assess the risk of cancer recurrence up to 20 years after diagnosis. 

The test, called MammaPrint, was devised by UCSF cancer researcher Laura van't Veer, a co-author of the new study that involved 1,780 patients.

The results suggest that the 70-gene test can be used to help physicians and patients determine their treatment course, and to inform choice of systemic therapy as well as local therapy. 

"There are breast cancers that pose little or no systemic risk," said Esserman. 

"Women who have a tumour that is classified as ultralow risk by 70-gene signature can be reassured that their long-term outcome is expected to be excellent," Esserman added.




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New Delhi: Dark chocolate nowadays is popularly known as one of the best superfoods. If you nibble dark chocolate to satisfy a craving, youre also helping your heart with every bite, say experts.

Sonia Narang, Wellness and Nutrition Expert, Oriflame India and Meher Rajput, Nutritionists and Dietician, FITPASS share that how dark chocolates can be healthy too.


* Dark chocolate is also pre-loaded with decent amounts of soluble fibre and potential minerals. It contains Oleic acid, Stearic acid and Palmitic acid.

* Loaded with organic compounds which are biologically active, dark chocolate can help lower blood pressure and improve the flow of blood in your body. It greatly helps in decreasing the levels of oxidised LDL Cholesterol in men.

* Eating dark chocolate (which has 65 percent polyphenol-rich cocoa) helps to lower blood pressure naturally.

* Flavanols found in dark chocolate help in improving your heart health by lowering blood pressure and refining the flow of blood to the heart as well as to the brain. They also help in reducing the risk of cancer.

* Dark chocolate also reduces the level of insulin resistance, which is a very common factor behind the birth of diseases like Diabetes, Cardiovascular disease, and other heart ailments.

* Dark chocolate also has high concentration of an alkaloid called theobromine which has stimulant properties and relaxing effects. It can dilate the blood vessels.





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NEW DELHI: Starting annual screening for breast cancer from age 40 may help reduce deaths due to the disease by nearly 40 per cent, researchers say.

If "women choose to start annual screening mammography starting at age 40, over the long term, this would be significant because fewer women would die from breast cancer", said lead author Elizabeth Kagan Arleo from the New York-Presbyterian Hospital in New York City.


In the study, published in the journal Cancer, the researchers compared the number of deaths that might be prevented as a result of three of the most widely discussed recommendations for screening mammography.

They used computer modelling to estimate the possible effects of three schemes: annual screening starting at 40 years, annual screening at ages 45 to 54 years and then biennial screening at ages 55 to 79 years, and biennial screening at ages 50 to 74 years.

The findings showed that recommendation of annual screening starting at age 40 would result in the greatest reduction in breast cancer-specific deaths with a nearly 40 per cent reduction in deaths, compared with 23 per cent to 31 per cent reductions with other recommendations at older ages.

The researchers also considered risks associated with screening, including callbacks for additional imaging and, in some cases, a needle biopsy, both of which may reveal the absence of breast cancer despite a suspicious mammography finding.

The findings may provide valuable guidance to women and their physicians about choosing a screening regimen.








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New Delhi:  Cigarette butts (CBs) thrown into garbage as trash can be turned into a valuable resource for killing mosquitoes that cause malaria, a new study by an international team, including from India, has revealed.

This novel method for pest control -- using CBs for the synthesis of silver nanostructures -- has been reported by the international of scientists in the latest issue of the journal Environmental Science and Pollution Research.


Besides nicotine -- a known poison -- CBs contain a mixture of toxic substances including heavy metals, Kadarkarai Murugan, lead author and Vice Chancellor of Thiruvalluvar University at Vellore, told this correspondent in an email.

The researchers report experiments with water extracts of CBs collected from the campus of the Bharathiar University in Coimbatore, another participating institution from India.

Scientists from Italy, Saudi Arabia, Taiwan and Malaysia also participated in the study, during which they used the CB extract as a source to synthesise silver nanoparticles.

According to their report, "A single treatment with CB extracts and silver nanostructures -- synthesised using the extract -- significantly reduced egg hatchability of 'Anopheles stephensi', the mosquito species that spreads the 'P. falciparum' malaria parasite."

Low doses of the silver nanostructures also inhibited the growth of a soil bacteria (Bacillus subtilis), the organism (Klebsiella pneumoniae) that causes pneumonia and "Salmonella typhi", that causes typhoid, says the report.

Normally, the larvae of malaria mosquitoes in water are eaten by their predators -- small crustaceans called M. aspericornis -- and thus naturally get eliminated before they become adult mosquitoes.

According to the researchers, who evaluated the impact of their nanomaterial in an aquatic environment, the predation efficiency of these useful crustaceans was not affected by the introduction of CB-synthesised nanoparticles.

Smoke toxicity experiments conducted against adult mosquitoes showed that "CB-based coils led to mortality comparable to the standard pesticide permethrin", the report says.

CBs are one of the most ubiquitous forms of garbage with an estimated environmental burden of 4.5 trillion butts discarded annually.

"Overall, the present research would suggest that an abundant hazardous waste, such as cigarette butts, can be turned into an important resource for nanosynthesis of novel insecticides highly effective against young instars and adults of the A. stephensi chloroquin resistant P. falciparum malaria parasite and microbial pathogens," says the report.

Considering the growing threat of drug-resistant P. falciparum strains, the CB synthesized nanomaterial "can be considered for the development of an alternative" approach for treating and controlling chloroquin resistant malaria parasites.

Payyalore Rajagopalan, former director of the Vector Control Research Centre in Pondicherry, said that nicotine is a known mosquito killer. "But the authors have done a lot of work and it needs to be encouraged," he told this correspondent in an email.






(This story has not been edited by dailyaddaa staff and is auto-generated from a IANS feed.)





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New Delhi: Australia snapped India's nine-match ODI winning steak on Thursday as they had a last laugh in the fourth ODI in Bengaluru beating India by a margin of 21 runs. David Warner and Aaron Finch's 231- run stand and Peter Handscomb's late flourish helped them score a mammoth 334 in 50 overs. Chasing a big total, Ajinkya Rahane and Rohit Sharma gave India a solid start but quick wickets of the openers and then Virat Kohli jolted the hosts' progress. Kedar Jadhav and Hardik Pandya led the recovery and were going great guns before the latter fell for 41 at the crucial juncture. Jadhav's wicket in the 46th over stuttered the hosts and MS Dhoni's departure in the last ball of the 48th over was the final nail in the coffin. Australia opened their account in the series but still Virat Kohli and men lead the five-match series 3-1 with the final match being scheduled to be played on October 1.

Australia opened their account in the series but still Kohli and men lead the five-match series 3-1 with the final match being scheduled to be played on October 1 in Nagpur.

Courtesy Warner's spectacular ton in his 100th game, Australia put up a commanding score but it was the pace troika of Pat Cummins (1/59 in 10 overs), Kane Richardson (3/58 in 10 overs) and Nathan Coulter-Nile (2/56 in 10 overs), who delivered in the slog overs to stifle the Indian batsmen.

Manish Pandey (33) and Jadhav (65) added 61 runs for the fifth wicket but both paid for their indiscretion as their dismissals in quick succession brought Australia back in the match.

Dhoni (13 off 10 balls) failed to connect majority of his deliveries, playing as many as six dot balls during the final overs, proving to be too costly.

Once again it was evident that Dhoni's finishing powers are on the wane and he is happier playing second fiddle. Testimony to Australia's domination at the death was that overs 47, 48, 49 and 50 produced 6, 6, 5 and 7 runs respectively.

However, India's chase started in right earnest as Rohit and Rahane adding 106 runs in 18.2 overs.

The duo played some classy shots -- especially Rohit, who hit as many as five effortless sixes compared to a boundary. Rahane at the other end dropped anchor hitting six boundaries and a six with India in cruise control mode.

In the 19th over, Rahane failed to clear Aaron Finch off Kane Richardson delivery and Rohit was unfortunately run-out -- partly due to Steve Smith's brilliance and mix-up with skipper Virat Kohli.

Kohli (21) got set before he played on off Nathan Coulter-Nile for the second time in the series as India were suddenly in a spot of bother at 147 for 3.

Man of the moment Hardik Pandya (41) was then joined by Jadhav to add 78 runs for the fourth wicket.

It was Pandya, who started to take on the bowling, especially leg-spinner Adam Zampa as he hit a boundary and three sixes.

Jadhav started slowly but then picked up pace and matched Pandya stroke for stroke.

Just when they had settled down with a nice partnership, Zampa dropped one short and Pandya was taken at long-off by Warner.

Earlier, Warner hit a splendid century in his 100th ODI as Australia put up a commanding total of 334 for 5 against India in the penultimate encounter of the five-match series, here today.

Warner (124 off 119 balls), who struck his 14th ODI hundred in his milestone match adding 231 for the opening stand with in-form Aaron Finch (94).

Australia were looking good for a total close to 400 but the Indian bowlers pulled back in the final 15 overs in which the visitors could manage only 103 runs.

Umesh Yadav was the pick of the bowlers despite being expensive as he had figures of 4 for 71 in 10 overs to show for his efforts.

Kedar Jadhav (1/38 in 7 overs) also did his bit to put brakes on the scoring after the openers raised visions of a mammoth total.

Warner, who have had a poor series till date, hit 12 boundaries and four sixes while Finch, who hit 10 boundaries and three sixes off 96 balls, missed out on a well-deserved hundred.

Their dismissals in quick succession did put a halt in scoring rate before Peter Handscomb's 43 off 30 balls and Marcus Stoinis' cameo (15 no off 9 balls) enabled them to cross the 330-run mark.

Kedar started it all by enticing Warner to go for a lofted shot which went straight to Axar Patel at long on and then next two wickets of skipper Steve Smith (3) and Finch were bagged by Yadav.

Incidentally, Smith's dismissal was Yadav's 100th victim in ODIs.

The stage was set for Australia to go after the Indian bowling, being comfortably placed at 248 for three in 40 overs but Travis Head (29 off 38 balls) struggled during the back-10 enabling India atleast curtail the Australian total by 20 runs.

Head was holed by Ajinkya Rahane at deep square leg fence off Yadav.

Handscomb was cleaned up by Yadav after he scored 43 balls off 30 balls with three boundaries and one six. Mathew Wade (3) and Stoinis remained unbeaten.

Earlier, a fluent approach by both Warner and Finch provided Australia a record first wicket partnership of 231 off 201 balls, beating the previous record of 212 scripted by Geoff Marsh and David Boon against India in Jaipur in 1986.

Their partnership was also the highest at Bengaluru, beating the previous best of 183 scored by Brad Haddin and Shane Watson against Canada in a 2011 World Cup match.


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New Delhi: Singer Rahul Vaidya is excited to come back on the Indian small screen as a host with upcoming singing reality show "Music Ki Pathshaala". He says the show will help children explore their talent further and get the right direction from celebrity mentors.

The show, which will be aired on &TV, will feature 20 contestants. This bi-weekly show will see new celebrity guests every week. The Kakkar sisters -- Sonu, Tony and Neha -- will be joining the show as the first celebrity judges.


"It feels great to be back and I am excited about 'Music Ki Pathshaala'. Times have definitely changed and it feels nice to see the kind of platforms available to kids these days. Such shows only help the aspiring kids to explore their talent further and get the right direction from celebrity mentors who have made a mark for themselves in the industry," Rahul said in a statement.

Rahul, who found popularity as an "Indian Idol" contestant, has hosted shows like "Jhoom India", "Aaja Mahi Vay" and "The Voice India Season 2".

Talking about "Music Ki Pathshaala", he said: "Since there is no elimination involved in the show, the participants will learn the nuances of music in a much-relaxed environment and get an opportunity to jam with the mentors. As the host of the show, you will see a new side to Rahul."


Mr. Vaidya recently pay his tribute to the King of romance and the Badshah of Bollywood - Shahrukh Khan. Must Watch Video.






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Mumbai: India's star shuttler P.V. Sindhu will be seen on the hot seat of popular game show "Kaun Banega Crorepati" (KBC). Megastar Amitabh Bachchan says he had an extraordinary meeting with her.

Amitabh, who called it "an honour and a moment of great pride" to be in Sindhu's company, also shared a few photographs of himself with her on his blog on Thursday.


"The icing on the cake would have to be this extraordinary meeting with the World Champion and pride of India," he wrote beneath a photograph featuring him with Sindhu.

In another image, the "Piku" star can be seen with folded hands.

He wrote: "This is the best that one can do in front of her (Sindhu's) greatness and her multiple achievements .. God bless you P. V. Sindhu and may you continue to bring greater glory to our nation."

(This story has not been edited by dailyaddaa staff and is auto-generated from a syndicated feed).





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CHENNAI: J Jayalalithaa was drowsy and had difficulty breathing, but could speak when she was brought to Chennai's Apollo hospital on September 22 last year, says the first medical report that was filed that day and has now been accessed by local media. The report noted that the then Tamil Nadu Chief Minister possibly had pneumonia and that her blood pressure, pulse rate and sugar level were high and oxygen in her body was at 43 per cent. Sources at Apollo hospital have refused to comment as the matter is in court.




Here is your 10-point cheatsheet to this big story:
  1. Much of this information matches the report of UK interventionist Dr Richard Beale after Ms Jayalalithaa's death in December last year. An inquiry commission has been set up to investigate her hospitalisation and death.


  1. The commission will also investigate the circumstances that led to the AIADMK chief being taken to hospital and her treatment, amid conspiracy theories around her illness and death, reinforced over the last week by leaders of the ruling party saying they were not allowed to see Ms Jayalalithaa in hospital.



  1. Retired high court judge Justice Arumugasamy, 65, who will investigate the circumstances of J Jayalalithaa's death, has been given three months to report his findings. An order on Wednesday evening indicated that the government has given the retired judge a free hand.



  1. O Panneerselvam, who is now Deputy Chief Minister, was the first top AIADMK leader to allege that there was more to Ms Jayalalithaa's death than what was made public, and had complained earlier this year that he did not get to see her in hospital, demanding an investigation.



  1. The inquiry commission was set up after the AIADMK faction led by Mr Panneerselvam, or OPS, merged with that led by Chief Minister E Palaniswami last month. An inquiry into their leader's death was a pre-condition set by the OPS camp for the reunion, a demand seen to target VK Sasikala, Ms Jayalalithaa's long-time aide, who was the only one allowed access to her at the hospital.



  1. Last week, the state's Forest Minister Dindigul Srinivasan apologised for party leaders making claims like they saw "Amma eating idlis" at the hospital in all-is-well reports. He said ministers lied because they were afraid of Ms Sasikala.



  1. Another minister OS Manian said yesterday that party leaders were not allowed to see the former chief minister at the hospital and were only briefed on her health by the hospital's chairman Prathap Reddy and the state's health secretary, J Radhakrishnan.



  1. But one minister, Sellur Raju, has said he and other colleagues had met Ms Jayalalithaa in hospital. The opposition DMK has demanded a CBI inquiry.
  2. VK Sasikala, who is in jail in a corruption case, assumed massive power as the only one who could access Ms Jayalalithaa during her hospitalisation and soon after her death on December 5 took over as the AIADMK chief.



  1.  Ms Sasikala and her nephew TTV Dinakaran, who she appointed as the AIADMK number 2, have been evicted from the party after the merger, but they are fighting back to regain control. Mr Dinakaran has claimed that Ms Sasikala shot a video of Ms Jayalalithaa in hospital but it cannot be made public as the former chief minister was "in a nightie."  






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New Delhi:  The morning after his extreme indictment of the government's role in the economic slowdown, veteran BJP leader Yashwant Sinha said "I stand by my analysis." Mr Sinha, a former finance minister, said "short-sighted" decisions are being rushed by the government of Prime Minister Narendra Modi and that there is no denying that the economy has hit a rough spot. "We used to blame the UPA (previous government) for policy paralysis," he said, "after 40 months in power, we can't (still) blame the earlier government," he told news agency ANI.

Yashwant Sinha, 79, stung his party yesterday with an opinion piece titled "I Need To Speak Up Now" in which he demolished Finance Minister Arun Jaitley and his handling of the economy, which fell to a three-year-low of 5.7 percent in the last quarter.

The government rejected his assessment. "Under the decisive leadership of PM Modi, India has become the world's fastest-growing economy for three years in a row," said union minister Piyush Goyal.
This morning, Mr Sinha's son, Jayant Sinha, who is a union minister, wrote an article for the Times of India in which he countered his father, declaring that criticism of the economy in recent articles "draw sweeping conclusions from a narrow set of facts, and quite simply miss the fundamental structural reforms that are transforming the economy."

His father today said that claims of the last quarter as an anomaly to the government's economic accomplishments cannot be accepted because the economy has been sliding for years now. He also repeated his criticism of the government's rushed introduction of the landmark GST or national sales tax, stating that its hurried implementation is hurting businesses.








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Mumbai:  Actor Nawazuddin Siddiqui, who is elated that his mother Mehroonisa Siddiqui has been named as one of the most influential women in India by the BBC, shared his happiness on Twitter by posting a photograph featuring him with his mother. The mother-son duo can be seen embracing each other in the picture posted by the 43-year-old actor. "A lady who showed courage against all odds being in a conservative family from a small village-My Mother," wrote the Manjhi - The Mountain Man actor. Indian women's cricket team captain Mithali Raj, Dr. Urvashi Sahni, who is a social entrepreneur, women's rights activist and educationist and Nitya Thummalachetty, who is a business analyst at CareCentra, a health care analytics company in New York also feature in BBC's 100 most influential women list of 2017.

See the picture posted by Nawazuddin Siddiqui here:


Nawazuddin Siddiqui made his Bollywood debut in 1999 with a small role in Aamir Khan's Sarfarosh. He gained popularity after he featured as a journalist in Anusha Rizvi's Peepli Live (2012).
Nawazuddin Siddiqui has featured in successful films like Kahaani, Gangs of Wasseypur, Talaash, Bajrangi Bhaijaan, Manjhi - The Mountain Man and Haraamkhor, for which he won the Best Actor award at the New York Indian Film Festival.

In 2012, Nawazuddin Siddiqui received the Special Jury Award at the National Film Awards.

Nawazuddin Siddiqui last featured in the short film Carbon, co-starring Jackky Bhagnani and Prachi Desai. He will next feature in Nandita Das' Manto. The film is scheduled for release in December this year.






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