Scientists Have Found A New treatment Which Might Help Repair Cardiac Muscles After Heart Attack

Scientists Have Found A New treatment Which Might Help Repair Cardiac Muscles After Heart Attack

Scientists Have Found A New treatment Which Might Help Repair Cardiac Muscles After Heart Attack(Representationla Image)

New Delhi: A new study has identified a way to repair the damaged heart muscles and also recover almost all of its pumping function after a heart attack.

At the time of a heart attack, the organ is starved of oxygen and the muscles are damaged. On identifying the damage, the body responds by sending in immune cells to clear up dead and dying cells, but these cells themselves cause further inflammation in the already damaged heart further leading to heart failure.
The study published in Journal of Clinical Investigation, was conducted by the team by injecting a protein called VEGF-C in mice after heart attack.

The result they found out was that the VEGF-C treatment promoted growth of a network of vessels which are part of the lymphatic system.

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The extra lymphatic vessels prevent the significant damage from inflammation by allowing the immune cells to be quickly cleared after helping to repair and clear dying and dead cells.

According to the team, the healing in the heart and the recovery in the heart's pumping function was found to be better with this treatment.
Once macrophages, the first line of immune cells that start the healing process, are cleared, other immune cells called Tregs could then be allowed into the injured muscle, to further help the heart to repair and recover.

"We started looking at the lymphatic system in the heart a few years ago - we could never have known how pivotal it might turn out to be for heart repair," said Paul Riley from University of Oxford.

Riley went on to add," This research has allowed us to start a drug discovery programme to develop drugs to promote the growth of lymphatic vessels and quickly clear immune cells. We hope to get a treatment we could give to people after a heart attack within five to 10 years." 

(Inputs from News Agency IANS)

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