Sam Allardyce side Crystal Palace continued their recent revival to boost their English Premier League survival hopes and leave Arsene Wenger side Arsenal struggling to maintain their run of top-four finishes.
The Eagles led through midfielder Andros Townsend's close-range finish, doubling their lead when the France International Yohan Cabaye's shot looped in.
Serbian midfielder Luka Milivojevic clinched win with a firm, low penalty as Crystal Palace moved six points clear of the relegation zone.
The Gunners did not manage a shot on target in a poor second half.
Some travelling Arsenal fans again called for coach Wenger, who has led sixth-placed Arsenal to top-four finishes in each of his previous 20 seasons at the helm, to leave the club.
The Gunners are seven points afloat of fourth-placed Pep Gaurdiola’s Manchester City with eight matches remaining.