David Moyes side Sunderland's hopes of bypass relegation suffered another setback as Jose Mourinho side Manchester United eased to win to climb to fifth in the points table.
Bottom club Sunderland played with 10 men for more than 45 minutes after Sweden forward Sebastian Larsson's controversial red card for a challenge on United’s midfielder Ander Herrera.
The Former Sweden striker Zlatan Ibrahimovic had already put the Red Devil’s ahead with a sublime, curling 20-yard effort.
The Armenian midfielder Henrikh Mkhitaryan made it 2-0 before forward Marcus Rashford drilled in the third.
The Black Cats are 10 points from safety with just seven matches left and have not scored for seven games.
Manchester United, who move above Arsene Wenger side Arsenal, are four points behind fourth-placed Manchester City with one match in hand over their neighbours.